منابع مشابه
A paradigm shift in myocardial stunning.
this lateralization may result in a change in anisotropy, which was supported by our rat model. In that model a higher degree of lateralization was seen than observed in human chronic AF. However, it is difficult to extrapolate from the rat experiments to the human immunostaining results, for we cannot know how much of the protein positively staining for connexins resembles functional channels....
متن کاملPreconditioning: a paradigm shift in the biology of myocardial ischemia.
The discovery of preconditioning (PC) has arguably been the single most important development in the field of ischemic biology in the past 20 years. The significance of this phenomenon transcends cardiovascular medicine, since it is ubiquitously observed in virtually every tissue of the body. This article reviews the pathophysiology and molecular basis of myocardial PC, with particular emphasis...
متن کاملMyocardial Stunning in Dogs
This study was undertaken to elucidate whether cal-adrenoceptor activity is beneficial to contractile dysfunction during reperfusion after a brief period of ischemia (stunned myocardium) in 54 open-chest dogs. Contractile dysfunction assessed by fractional shortening (FS) was observed 3 hours after the onset of reperfusion following 15 minutes of complete occlusion of the left anterior descendi...
متن کاملA Methodology for Paradigm Shift to Explain Sustainable University
The sustainable university concept is rooted in prevalent paradigms pertained to economic, social and environmental development, which all focus on systemic thought and rationality; besides, they tend to discover and solve problems by applying an interdisciplinary approach. However, the epistemic component is what these paradigms have ignored. The purpose of this study is to explain a methodo...
متن کاملMechanism of myocardial "stunning".
Among the numerous mechanisms proposed for myocardial stunning, three appear to be more plausible: 1) generation of oxygen radicals, 2) calcium overload, and 3) excitation-contraction uncoupling. First, the evidence for a pathogenetic role of oxygen-derived free radicals in myocardial stunning is overwhelming. In the setting of a single 15-minute coronary occlusion, mitigation of stunning by an...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2002
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(02)01817-x